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Guanine's N7 position is exposed in the major groove of double-helical DNA, making it more suitable for adduction than when compared to adenine's N3 position, which is orientated in the minor groove

Johansson MEV, Hansson GC

() : Glutathione : 5

No dose adjustments should be required for triazolam or other sedative hypnotics in patients cotreated with dexamethasone, given that its moderate inducer activity on CYP3A4 occurs at high doses (above 1624 mg/day) [86]

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